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🫀C9. Cardiac Muscle; The Heart as a Pump
1. Physiology of Cardiac Muscle
1.3 Excitation-contraction coupling
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Cards (20)
What does the term "excitation-contraction coupling" refer to?
Mechanism causing muscle contraction from
action potential
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How does excitation-contraction coupling differ in cardiac muscle compared to skeletal muscle?
Cardiac muscle has additional
calcium influx
from
T tubules
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What spreads the action potential in cardiac muscle fibers?
Transverse (T) tubules
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What triggers the release of calcium ions into the muscle sarcoplasm?
Action potential
acting on
longitudinal sarcoplasmic tubules
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What role do calcium ions play in muscle contraction?
They catalyze reactions for
actin
and
myosin
sliding
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What are ryanodine receptor channels responsible for?
Triggering
calcium release
from the
sarcoplasmic reticulum
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Why is calcium from T tubules important for cardiac muscle contraction?
It compensates for less calcium stored in
sarcoplasmic reticulum
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How much larger are the T tubules in cardiac muscle compared to skeletal muscle?
Five times larger
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What is the effect of extracellular calcium concentration on cardiac muscle contraction?
It significantly affects
contraction strength
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What happens to a heart placed in a calcium-free solution?
It quickly stops
beating
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How does the T tubule system relate to extracellular fluid in cardiac muscle?
It allows
extracellular fluid
to
percolate
through
T tubules
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How does skeletal muscle contraction differ in response to extracellular calcium concentration changes?
It is hardly affected by moderate changes
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What happens to calcium ions at the end of the cardiac action potential?
They are pumped back into the
sarcoplasmic reticulum
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What pump helps transport calcium back into the sarcoplasmic reticulum?
Calcium–adenosine triphosphatase
(
ATPase
) pump
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What is the role of the sodium-calcium exchanger in cardiac muscle?
It removes
calcium ions
from the cell
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What happens to contraction after calcium is removed from cardiac muscle fibers?
Contraction ceases until a new
action potential
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How long does cardiac muscle contraction last after the action potential begins?
A few
milliseconds
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What primarily determines the duration of cardiac muscle contraction?
Duration of the
action potential
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How long is the duration of contraction in atrial muscle?
About
0.2 seconds
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How long is the duration of contraction in ventricular muscle?
About
0.3 seconds
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