1.3 Excitation-contraction coupling

Cards (20)

  • What does the term "excitation-contraction coupling" refer to?
    Mechanism causing muscle contraction from action potential
  • How does excitation-contraction coupling differ in cardiac muscle compared to skeletal muscle?
    Cardiac muscle has additional calcium influx from T tubules
  • What spreads the action potential in cardiac muscle fibers?
    Transverse (T) tubules
  • What triggers the release of calcium ions into the muscle sarcoplasm?
    Action potential acting on longitudinal sarcoplasmic tubules
  • What role do calcium ions play in muscle contraction?
    They catalyze reactions for actin and myosin sliding
  • What are ryanodine receptor channels responsible for?
    Triggering calcium release from the sarcoplasmic reticulum
  • Why is calcium from T tubules important for cardiac muscle contraction?
    It compensates for less calcium stored in sarcoplasmic reticulum
  • How much larger are the T tubules in cardiac muscle compared to skeletal muscle?
    Five times larger
  • What is the effect of extracellular calcium concentration on cardiac muscle contraction?
    It significantly affects contraction strength
  • What happens to a heart placed in a calcium-free solution?
    It quickly stops beating
  • How does the T tubule system relate to extracellular fluid in cardiac muscle?
    It allows extracellular fluid to percolate through T tubules
  • How does skeletal muscle contraction differ in response to extracellular calcium concentration changes?
    It is hardly affected by moderate changes
  • What happens to calcium ions at the end of the cardiac action potential?
    They are pumped back into the sarcoplasmic reticulum
  • What pump helps transport calcium back into the sarcoplasmic reticulum?
    Calcium–adenosine triphosphatase (ATPase) pump
  • What is the role of the sodium-calcium exchanger in cardiac muscle?
    It removes calcium ions from the cell
  • What happens to contraction after calcium is removed from cardiac muscle fibers?
    Contraction ceases until a new action potential
  • How long does cardiac muscle contraction last after the action potential begins?
    A few milliseconds
  • What primarily determines the duration of cardiac muscle contraction?
    Duration of the action potential
  • How long is the duration of contraction in atrial muscle?
    About 0.2 seconds
  • How long is the duration of contraction in ventricular muscle?
    About 0.3 seconds