Alzheimer’s disease

• What is the most common cause of dementia in the UK?

  Alzheimer’s disease
• Which age group is most commonly affected by Alzheimers disease?

  65 or over
• Which gender is more likely to develop alzheimer’s disease?

  Women
• What is the hallmark feature of Alzheimer’s disease in the brain?

  Amyloid plaques
• Which enzyme is involved in the cleavage of amyloid precursor protein (APP) in Alzheimer’s disease?

  Beta-secretase
• Tau tangles in Alzheimers disease result from hyper phosphorylation of which protein?


  Tau
• Which of the following cognitive tests is commonly used to assess memory, orientation and problem solving skills in Alzheimer’s diagnosis?

  Mini-Mental State Examination (MMSE)
• Which of the following brain regions is particularly affected by shrinkage (Atrophy) in Alzheimer’s disease?

  Hippocampus
• Which medication is used to increase acetylcholine levels in the treatment of Alzheimer’s disease?

  Donepezil
• What is the role of Memantine in Alzheimer’s disease management?

  Regulates glutamate activity
• What brain feature is commonly seen in Alzheimer’s patients on MRI scans?

  Brain atrophy
• Which of the following is a generic factor associated with alzheimer’s disease?

  APOE*4 allele and PSEN2 mutation
• What is the main cause of nueron death in alzheimer’s disease?

  Abnormal protein accumulation.
• Memantine is a treatment in alzheimer's disease that targets which of the following proteins?

  NMDA receptors
• What is the primary function of the tau protein in healthy neurons?

  Stabalising microtubules for nutrient transport