Aztreonam

• Aztreonam is a synthetic monobactam antibiotic, having a moncyclic nucleus.
• Aztreonam inhibits synthesis of the bacterial cell wall by high-affinity binding to penicillin-binding protein (PBP3 ) which is found primarily in aerobic, Gram-negative microbes.
• Aztreonam is highly resistant to beta-lactamases.
• Aztreonam is effective in treating Gram-negative UTI, lower respiratory tract, skin, intraabdominal, gynecologic infections and septicemia.
• Contraindications for Aztreonam include

  • hypersensitivity history to penicillin or cephalosporins;
  • impaired renal or liver function.
• Aztreonam exhibits activity against

  • Hemophilus influenzae,
  • Pseudomonas aeruginosa,
  • Neisseria gonorrhoeae
  • E . coli,
  • Enterobacter,
  • Klebsiella,
  • Proteus,
  • Shigella,
  • Salmonella, 
• Aztreonam is administered either IV or IM