CASE STUDY/ DNP Reactions

• DNP is a molecule that uncouples the ATP synthesis reaction
• DNP is a weak hydrophobic acid
• DNP creates an equilibrium between the H+ ions (or pH) on both sides of the gradient which prevents the gradient from being created and inhibits the process of ETC
• DNP is mostly hydrocarbon, and it moves through the membrane easily since its hydrophobic
• DNP equilibrates the H+ ions
• If there is no gradient formed no ATP will be produced
• DNP adds to non shivering thermogenesis, and brown fat which is hypogenit