The opposition somewhat disappeared with the introduction of a 'conscience clause' in the Smallpox Act in 1898 and by the end of the year, over 200000 exemption certificates had been issued. In 1875, only 4% of all registered births in England and Wales were of unvaccinated babies, but by 1898 this had risen to 27%. However, despite the lack of vaccinations, the deaths from smallpox continued to decrease.