Salivaria (Anterior)

• T. Brucei gambinese?

  West africa, causes Gambian trypanosomiasis

  Chronic sleeping sickness

  
• T. brucei rhodesinse?

  Found in east Africa, causes Rhodesian trypaosomiasis

  Acute sleeping sickness

  
• What happens to trypanosomes in the fly? (1)

  Trypomastigotes are ingested in a blood meal then are reproduced in the mid gut
• What happens to trypanosomes in the fly? (2)

  They move to the salivary gland to reproduce and become epimastigotes
• What happens to trypanosomes in the fly? (3)

  Epimastigotes become metacystic trypomastigotes and are then injected into the vert
• What happens to trypanosomes in the 'vert? (4)

  They live in the blood stream as trypomastigotes and divide
• What happens to trypanosomes in the fly?

  The invade the CNS and cause chronic infection
• What is the pathology?

  Occurs rarely in the brain, causes lymph imflammation

  Death occurs in a few months
• T. b. gambinese occurs in the brain
• What happens to the trypanosome?

  antigen variations (VSG)

  
• How is it diagnosed?

  Finding the parasite within the lood
• How are trypanosomes controlled?

  Through vectors and reservoir hosts