Methotrexate

• How does methotrexate & aspirin interact?

  Aspirin stops excretion of methotrexate -> build up
• How do methotrexate & penicillin interact?

  If too much penicillin given, can stop methotrexate from being excreted
• What are the red flag symptoms of methotrexate?

  Ulcers

  Persistent sore throat

  Dark urine

  SOB
• Why is folic acid given with methotrexate?

  Methotrexate stops the production of folic acid - by inhibiting dihydrofolate reductase

  Need to supplement to increase folate levels
• How often is methotrexate given for RA?

  Once weekly

  Education is important
• Can alcoholics take methotrexate?

  No, this is contraindication as methotrexate can cause cirrhosis
• What is methotrexate?

  Anti-folate & anti-neoplastic agent
• What are the indications of methotrexate?

  Crohn's

  Rheumatoid arthritis

  Neoplastic diseases
• What are the side effects of methotrexate?

  Anaemia

  GI discomfort

  Nausea
• What monitoring is required for methotrexate?

  FBC, U&Es, LFTs every 2-3 months