Creutzfeldt-Jakob disease (CJD) leads to the destruction of nerve tissue and neurological symptoms.
Bacteriophage Lambda, Papilloma virus, tobacco mosaic virus, Influenza virus, Adenovirus, Bacteriophage T4, Corona virus are examples of viruses and phages
Viruses are not living entities and require the machinery of the host cell to replicate
Viruses are obligateintracellularparasites and infect all organisms on earth
Viruses are a source for genetic diversity
Phospholipid bilayer from the host is involved in the attachment of viruses to the host cell
Comparative genomics shows the genome size of selected viroids, viruses, and prokaryotic cells
The CRISPR immune system: Clustered regularly interspaced short palindromic repeats.
Poliovirus causes Poliomyelitis and can lead to flaccid paralysis of the limbs, especially in children.
The Lytic Human Herpesvirus Life Cycle: Binding, Entry, Release and Nuclear Transport, Nuclear Entry, Gene Expression, DNA Replication, Packaging, Egress.
Poliovirus belongs to the Picornaviridae family and has positive-sense RNA molecules.
Most viruses are lytic and very few are known to cause cancer.
Retroviruses have Gag, Pol, and Env proteins and their lifecycle involves attachment to cell receptors, fusion with the plasma membrane, and trafficking to nuclear pore complexes.
The Baltimore classification categorizes viral genomes into seven classes based on their composition and replication strategy
Bacteriophages use different receptors to infect Escherichia coli
MS2 is a small (+) RNA phage with a genome of 3569 nucleotides and encodes fourproteins.
Cas proteins store pieces of phage DNA as a memory of infection and use these memories to find and destroy matching phage genomes.
Bacteria have defense systems, such as blocking adsorption, injection, or assembly, cell suicide, or RM systems, to fend off phage infection.
M13 is a single-stranded DNA phage that uses Escherichia coli as a host for replication.
φ X174 is a filamentous phage and belongs to the Inoviridae family.
PAM sequences prevent CRISPR enzymes from cutting the repeat-spacer array.
CRISPR is an adaptive immune system found in bacteria and archaea that defends against specific types of phages.
The replication cycle of a lytic bacteriophage involves attachment to the host cell, injection of the viral genome, and replication
The one-step growth curve is a measure of viral replication
CI bound to two operator sites recruits RNA polymerase for transcription of cI and the anti-phage defense system.
The phage lambda-encoded functions and host encoded functions impact the lysis-lysogeny decision and control the lytic gene expression cascade.
The c I gene product binds to operator sites in the Lambda genome to execute the lysis-lysogeny decision.
The lysogenic cell can also be induced to form and lyse a mature virus.
Phi-X174 has been used as a model system for the study of prokaryoticDNAreplication, geneexpression, and morphogenesis.
Phi-X174 is a phage with a single-stranded DNA genome that was the first organism to have its whole genome sequenced in 1977.
The Lambda switch harmonizes multiple signals from the host cell state and infection status to commit to a lytic or lysogenic lifestyle.
Spanins activate after peptidoglycan degradation and cause fusion of the inner and outer membranes, leading to the release of phage progeny.
The alternatives after infection by bacteriophage Lambda are replication and release of a mature virus (lysis) or integration of the virus DNA into the host DNA (lysogeny).
At high concentrations, CI binds a third operator site and inhibits transcription governed by RNA polymerase.
Virions are exocytosed to complete the life cycle
Viral RNA enters the cytoplasm and ORF1a or ORF1ab is translated by the host ribosome
Prion diseases are neurodegenerative disorders caused by misfolded, aggregated proteins known as prions
Viral RNA and host proteins are packaged into nascent budding particles
Viral polyproteins are cleaved into NSPs and assemble into replication and transcription complexes
Progeny virions are assembled in the endoplasmic reticulum and Golgi body