The nerve impulse arrives at the pre-synaptic terminal, causing the synaptic vesicles to travel down to the pre-synaptic membrane. The pre-synaptic membrane and synaptic vesicle fuse, causing the release of neurotransmitters into the synaptic cleft. The neurotransmitters diffuse across the synaptic cleft towards the post-synaptic terminal, where they bind to post-synaptic receptors. As a result, the receptors change shape and allow charged particles to flow into the post-synaptic terminal, creating small changes in voltage in the neuron. Once there is a large enough change in voltage, a nerve impulse is triggered. Meanwhile, the neurotransmitters are released back into the synaptic cleft, where they are sucked back into the pre-synaptic membrane by re-uptake proteins.