what types of imaging are used for brain + head tumors?
somatostatin receptor scintigraphy
PET, PET/CT with 18F-FDG
What Rf is used in somatostatin receptor scintigraphy?
111-In-DTPA-tyr- octreotide (similar to somatostatin and attaches to tumor cells with receptors for somatostatin)
99mTc-DTPA-tektrotyd
what is the procedure for 111-In-DTPA-tyr-octreotide in somatostatin receptor scintigraphy?
Application of RF at 200 MBq
Imaging is taken the next day, takes 90-120min
Whole body scan
what is the procedure for 99mTc-DTPA-tektrotyd in somatostatin receptor scintigraphy?
Application of RF at 740 MBq
Patient has to be fasting
First picture is done after 2h
Whole body scan is done after 4 hours + SPECT/CT, takes 90-120min
In some cases, two images are taken after 24h
what is 18F-FDG?
a positron emitting radiopharmaceutical used for diagnostic purposes with PET scan
how does 18F-FDG work in finding cancer cells?
18F-FDG is a glucose analog, therefore it’s taken up by high glucose-using cells such as cancer cells and is not able to move out of the cell until radioactive decay
advantages of 18F-FET?
Performs much better than 18F-FDG PET for the diagnosis of primary brain tumors.
18 F-FET PET imaging also improves disease monitoring by early identification of tumor recurrence and progression.
