Noradrenaline

• What is noradrenaline?

  Sympathomimetic (stimulates sympathetic NS)
• What is the pharmacology of noradrenaline?

  Target: Adrenergic receptors (a1, a2, b1, b2)

  Action: Agonist
• MOA - Noradrenaline

  Binds to...

  • a1 adrenergic receptor -> vasoconstriction (skin & GIT), sphincter contraction
  • a2 adrenergic receptor -> decreased platelet aggregation
  • b1 adrenergic receptor -> increase HR, increase AV node conduction, increased contractibility of ventricular muscle, increased renin secretion
  • b2 adrenergic receptor -> vasodilation (skeletal muscle), bronchiole relaxation
• What are the indications of noradrenaline?

  Acute hypotension
• What are the side effects of noradrenaline?

  Headache

  Anxiety

  Ischaemia
• What is the monitoring required for noradrenaline?

  Monitor BP