Agonist substitution: methadone

• What is an agonist?

  • A chemical that binds to a receptor and activates it to produce a response, mimicking another substance (e.g., heroin).
• What is methadone used for?

  • Treating opioid addiction by reducing cravings and withdrawal symptoms while not producing the same "high" as heroin.
• How is methadone administered?

  • Orally (green liquid, tablet, or injection) to avoid needle-related risks.
• What is the recommended dosage for methadone treatment?

  • Initial dose: 10-40 mg daily

  • Increase: Up to 10 mg daily

  • Maintenance dose: 60-120 mg daily
• Why is supervision important in methadone treatment?

  • To prevent overdose, ensure correct dosage, and stop users from selling methadone.