• Antabuse prevents alcohol metabolism by blocking the enzyme aldehyde dehydrogenase, causing a build-up of acetaldehyde which leads to unpleasant symptoms.
What unpleasant symptoms occur after consuming alcohol with Antabuse?
• Symptoms include:
Sweating
Heart palpitations
Headaches
Vomiting
What is the process of classical conditioning with Antabuse?
Before learning: Antabuse (UCS) → Vomiting (UCR)
During learning: Antabuse (UCS) + Alcohol (NS) → Vomiting (UCR)
After learning: Alcohol (CS) → Vomiting (CR)
What are the NICE guidelines for using Antabuse in the UK?
Treatment starts after withdrawal from alcohol.
200 mg daily as an initial dose (can be increased if needed).
Patients are monitored every two weeks for two months, then monthly for the next four months.
