Pharmacokinetics PART 2

Created by

Libby Jordan

Cards (14)

what is a pharmacokinetic profile ?
a graph of concencentration against time
What does MTC stand for on a pharmacokinetic profile ?
maximum tolerated concentration
what does MEC stand for on a pharmacokinetic profile ?
minimum effective concentration
where does the therapeutic range or window for a drug lie on a pharmacokinetic profile ?
between the minimum effective drug concentration and the maximum tolerated concentration of drug
what is Cmax ?
the maximum concentration of drug in the blood plasma
what is Tmax ?
time of maximum drug concentration in the plasma
what does the AUC (area under the curve) on a pharmacokinetic profile show ?
total drug exposure across time and can be used to calculate oral bioavailability (AUCoral vs AUCiv)
what determines the elimination half life of a drug ?

distribution and elimination
what is the elimination half life of a drug ?
The time taken for the drug concentration In the plasma to reduce by half
what are the sources of pharmacokinetic variability ?
genetics, diet, age, gender, smoking, alcohol, disease state, food as this effects gastric emptying time
how can renal impairment affect drug elimination half life ? and AUC ?
increases - drug is present in the blood over longer period of time
AUC increases as total exposure of drug over time is longer
what is the difference between pharmacokinetics and pharmacodynamics ?
pharmacokinetics is the study of what the body does to the drug and pharmacodynamics is the study of what the drug does to the body
what are the sources of pharmacodynamic variability ?
drug receptor status
genetic factors
drug interactions
tolerance
what are the sources of pharmacokinetic variability ?
compliance
dosing or medication errors
tissue and body fluid mass and volume
drug interactions