The Nephron as the Functional Unit

Cards (26)

  • What is the functional unit of the kidney?
    The nephron
  • How many nephrons does each human kidney contain?
    About 800,000 to 1,000,000
  • Why can't the kidney regenerate new nephrons?
    Because nephrons do not regenerate
  • What happens to the number of nephrons with age?
    It gradually decreases
  • How much do functioning nephrons decrease after age 40?
    About 10 percent every 10 years
  • What is the percentage decrease in functioning nephrons by age 80?
    About 40 percent
  • Why is the loss of nephrons not life-threatening?
    Adaptive changes in remaining nephrons
  • What are the two main components of each nephron?
    Glomerulus and tubule
  • What is the function of the glomerulus?
    To filter large amounts of fluid from blood
  • What is Bowman’s capsule?
    It encases the glomerulus
  • Where does fluid flow after Bowman’s capsule?
    Into the proximal tubule
  • What are the two segments of the loop of Henle?
    Descending and ascending limbs
  • What characterizes the thin segment of the loop of Henle?
    It has very thin walls
  • How does the thick ascending limb differ from the thin segment?
    It has much thicker walls
  • What is the macula densa?
    A plaque of specialized epithelial cells
  • What role does the macula densa play?
    It controls nephron function
  • What follows the distal tubule in the nephron?
    The connecting tubule
  • What do the cortical collecting tubules lead to?
    The cortical collecting duct
  • How many large collecting ducts are in each kidney?
    About 250
  • What do collecting ducts collect urine from?
    About 4000 nephrons
  • What are the differences between cortical and juxtamedullary nephrons?
    • Cortical nephrons:
    • Glomeruli in outer cortex
    • Short loops of Henle
    • Juxtamedullary nephrons:
    • Glomeruli near medulla
    • Long loops of Henle
  • How do the vascular structures differ between cortical and juxtamedullary nephrons?
    • Cortical nephrons:
    • Surrounded by peritubular capillaries
    • Juxtamedullary nephrons:
    • Long efferent arterioles
    • Specialized peritubular capillaries (vasa recta)
  • What is the role of the vasa recta in juxtamedullary nephrons?
    They help form concentrated urine
  • What do the vasa recta return toward?
    The cortex
  • Where do the vasa recta empty into?
    The cortical veins
  • What is the overall function of the nephron?
    • Formation of urine
    • Regulation of water and electrolytes
    • Excretion of waste products