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🚰 C26. Urinary System
2. Physiological Anatomy of the Kidneys
The Nephron as the Functional Unit
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Cards (26)
What is the functional unit of the kidney?
The
nephron
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How many nephrons does each human kidney contain?
About
800,000
to
1,000,000
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Why can't the kidney regenerate new nephrons?
Because
nephrons
do not
regenerate
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What happens to the number of nephrons with age?
It
gradually
decreases
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How much do functioning nephrons decrease after age 40?
About
10 percent
every 10 years
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What is the percentage decrease in functioning nephrons by age 80?
About
40 percent
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Why is the loss of nephrons not life-threatening?
Adaptive
changes in remaining
nephrons
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What are the two main components of each nephron?
Glomerulus
and
tubule
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What is the function of the glomerulus?
To filter large amounts of
fluid
from blood
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What is Bowman’s capsule?
It encases the
glomerulus
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Where does fluid flow after Bowman’s capsule?
Into the
proximal tubule
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What are the two segments of the loop of Henle?
Descending
and
ascending
limbs
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What characterizes the thin segment of the loop of Henle?
It has very thin walls
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How does the thick ascending limb differ from the thin segment?
It has much
thicker
walls
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What is the macula densa?
A plaque of specialized
epithelial cells
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What role does the macula densa play?
It controls
nephron
function
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What follows the distal tubule in the nephron?
The
connecting tubule
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What do the cortical collecting tubules lead to?
The
cortical collecting duct
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How many large collecting ducts are in each kidney?
About 250
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What do collecting ducts collect urine from?
About
4000
nephrons
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What are the differences between cortical and juxtamedullary nephrons?
Cortical nephrons:
Glomeruli
in outer cortex
Short
loops of Henle
Juxtamedullary nephrons:
Glomeruli near medulla
Long loops of Henle
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How do the vascular structures differ between cortical and juxtamedullary nephrons?
Cortical
nephrons:
Surrounded by peritubular capillaries
Juxtamedullary nephrons:
Long
efferent arterioles
Specialized peritubular capillaries (
vasa recta
)
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What is the role of the vasa recta in juxtamedullary nephrons?
They
help
form
concentrated urine
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What do the vasa recta return toward?
The
cortex
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Where do the vasa recta empty into?
The
cortical veins
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What is the overall function of the nephron?
Formation of urine
Regulation of water and
electrolytes
Excretion of
waste products
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