an impulse arrives at the end of a pre synaptic neurone and chemicals are released into the synapse and diffuse across the gap. On the other side of the synapse the neurotransmitter binds to the receptor molecule on the membrane of the post synaptic neurone which as the neurotransmitter binds to the receptor a new nerve impulse is stimulated in the post synaptic neurone, finally the chemical messenger diffuses back into the pre-synaptic neurone ready to be reused