LO1

• WBCs are produced in the bone marrow
• B cells mature in bone marrow
• T cells move from bone marrow to thymus to mature
• red pulp destroys old and injured RBCs
• white pulp contains concentration of lymphocytes
• Natural immunity is the first line of defence after an antigen exposure
• Natural immunity protects the host without memory
• Neutrophils are the the first cells to arrive at the site of inflammation
• Monocytes function as phagocytic cells
• If the immune system fails to develop and clear antigen sufficiently, host is considered immunocompromised
• acquired immunity develops after being exposed to an antigen through vaxx
• Inflammatory response release chemical mediators to minimize blood loss, wall of invader, activate phagocytes, and promote scar tissue formation
• What are 4 main defense mechanism?

  1. WBC action- granulocytes, monocytes, lymphocytes
  2. Inflammatory response- respond to injury and release chemical mediators