moodc

• Skeletal Muscle Regeneration - Creates an inflammatory response that recruits macrophages to the damage site
• Skeletal Muscle Regeneration - macrophages clear debris and use signalling pathways like Wnt to coordinate regeneration
• Skeletal Muscle Regeneration - satellite cells lie between the basal lamina and muscle fibres
• Skeletal Muscle Regeneration - satellite cells activate, migrate, fuse to the site, proliferate and differentiate asymmetrically, creating myoblasts and more satellite cells
• Skeletal Muscle Regeneration - Pax7 is required for satellite cell function and proliferation, and for the formation of myofibers
• Skeletal Muscle Regeneration - improved by Myf5, IGF1, IL-15 and follistatin
• Skeletal Muscle Regeneration - satellite -> myoblast -> multinucleated myotubes -> myofibers
• Skeletal Muscle Regeneration - angiogenesis is also required, so remember all the FGF2, VEGF, and PDGF stuff along with TGF beta and Hedgehog
• Skeletal Muscle Regeneration - ECM remodelling requires MMPs, for the degradation and reformation of molecules such as collagen, integrins, and fibronectin
• Cells with myogenic capacity include: satellite cells, myoblasts, mesenchymal cells, pericytes
• Myoblasts - form muscle fibers, differentiate into myotubes, and then myotomes, regulated by myogenin