they bind to complementary dopamine (D2) receptors on the postsynaptic membrane, preventing dopamine molecules from binding to these sites. resulting in an inhibitory effect, returning neurotransmission to a normal level.
eg.chloroprozamine
primarily treat positive symptoms
how do a-typical drugs work
Blockingdopaminereceptors, but rapidly dissociate from them, temporary blocking allows low levels of dopamine activity as it can still competitively bind with d2 receptors
eg. clozpaine
affects both positive and negative symptoms
side effects of typcial
Extrapyramidal side effects, such as tardive dyskinesia (parkinsonisms, movement disorder)
side effects of a typical
Weight gain - can result in type 2 diabetes and fatty liver disease
