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Chapter 7
Nucleophilic substitution
Good Leaving group
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Quang Nguyen
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The more
sterically
hindered the substrate, the
slower
the rate of substitution will be.
Good leaving groups
are the most stable weak bases.
Good leaving groups follow the
right
and
down
direction on the periodic table.
At equilibrium of a nucleophilic substitution favors products where the leaving group is a
weaker
base
than the nucleophile.