Lymphoid Organs

• What are the cells primarily involved in the immune response?

  Lymphocytes
• Where do lymphocytes mature? Namely what organs?

  Primary Lymphoid organs

  Bone Marrow and thymus
• Where do lymphocytes activate and differentiate?

  Secondary lymphoid organs
• Identify the cell: Nucleus is round dense in chromatin and stains deep blue, cytoplasm has few organelles and stains sky blue or robin egg blue?

  Lymphocyte
• It is the center of antigen independent lymphopoiesis?

  Bone Marrow
• What organ do B cells develop?

  Bone marrow
• Where do T-cells develop?

  Thymus
• Where is the point origin for B-cells and T-cells?

  Bone marrow
• It is the site of antigen dependent lymphopoiesis

  Secondary lymphoid organs
• It is the largest secondary lymphoid organ?

  Spleen
• In the spleen this is where RBCs are destroyed and iron is recycled?

  Red pulp
• In the spleen this is the site that contains lymphoid tissues around arterioles in a periarteriolar lymphoid sheath?

  White pulp
• What is the main function of lymph nodes?

  Filtration of lymhp
• This secondary lymphoid organ serves as a central collecting point for lymph fluid from adjacent tissues?

  Lymph node
• In the lymph node where does b-cell collect?

  Cortex
• In the lymph nodes where does B-cell proliferate when there is an ongoing infection?

  Germinal centers
• Where is the T-cell area in the lymph node?

  Paracortex
• What is the condition where the lymphocytes are activated in the lymph nodes when they are exposed to antigens? This enlarges the lymph node?

  Lymphadenopathy OR Lymphadenitis
• This secondary lymphoid organ is found in the membrane lining of the oral and pharyngeal cavities that response to pathogens entering thru inhalation or ingestion?

  Tonsils
• These are secondary lymphoid organs found in the gastrointestinal tract (Peyer's patches), respiratory and urogenital tracts?

  Mucosa-associated lymphoid tissue (MALT)
• These are secondary lymphoid organs that are an association of intraepidermal lymphocytes, most of which are t-cells?

  Cutaneous associated lymphoid tissues
• What are the stages of which a b-cell undergoes in process of maturation?

  1. PRO B-CELL
  2. PRE B CELL
  3. IMMATURE B CELL
  4. MATURE NAIVE B CELL
• This is the antigen independent stage of a B-cell where there is a rearrangement of genes that code for the heavy and light chains?

  Pro B cell
• What chromosome is used to code the heavy chain in b-cells?

  Chromosome 14\
• What chromosomes is used to code the light chain in b-cells?

  Chromosome 2 and 22
• This is the stage of B-cell development where it starts the synthesis of the μ (mew) heavy chain?

  Pre B cells
• What does a pre b cell need to express in order to move forward with its development?

  μ heavy chain associated with two "surrogate light chains"
• This development stage of b-cell where there is complete expression of IgM on the cell surface?

  Immature B cell
• What characteristic of B-cells are developed during the immature B cell stage?

  Central Tolerance
• If the immature B-cell is reactive towards self antigens what happens to the cell?

  Apoptosis
• This is a stage of B-cell maturation where both IgM and IgD are completely expressed?

  Mature Naive B-cells
• It is a kind of B-cell where only IgM is expressed on its surface?

  Marginal zone B ells
• It is a kind of B cell where IgM and IgD is expressed on its surface?

  Follicular B-cells
• Marginal B-cells remain at what organ?

  Spleen
• Follicular B-cells migrate to what organs?

  Lymph nodes and other lymphoid organ
• What cells help the b-cell to be long lived?

  Stroma cells of Bone Marrow
• This lymphocyte has an ellipsoidal shape and has a cartwheel appearance cytoplasm?

  Plasma Cell
• What antibody does plasma cells express?

  IgM
• In the initial exposure of a mature naive B-cell there what do you call the aggregation of the IgM and IgD receptors at one side of the cell?

  IgM capping
• It is the qualitative change of B-cells that changes the antibody expression from IgM and IgD to IgG, IgA and IgE?

  Class switching/ isotype switching