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Gene mutations
Base Pair insertion and deletion
Outcome of BPID (single)
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Created by
Mak Weng Huen Hailey (Tmjc)
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Cards (2)
(1) Truncated protein…
result in
premature STOP codon
translation
terminates prematurely
and the polypeptide will be
shorter
than
normal
results in
non-functional
protein
(2)
Different amino acids
after point of
insertion
or
deletion…
reading frame (
triplets
of
bases
) of the
genetic message
is
altered
from the
point
of
insertion
or
deletion
sequence
of
amino acids
is
completely different
from
original protein
from the
point
of
insertion
or
deletion
leads to non-functional protein
Results in frameshift mutation
