A limitation of determinism is the position of the legal system on responsibility. Determinism is inconsistent with the legal system as it says that choice is not always the cause of behaviour.
Our legal system works on the basis of responsiblity.
Deterministic views however, provide an excuse for undesirable behaviours.
e.g. Mobley, who killed a Pizza manager in 1981 claimed that he was born to kill due to a history of violence in his family but his argument was rejected and he was sentenced to death.
BUT there are more recent examples where genetic evidence has been able to be used to reduce sentences in serious violent crimes.