Nucleo / electrophiles

• Nucleophile "loves" nucleus
• Electrophile "loves" electrons
• Nucleophiles usually bear negative charge
• Electrophiles usually bear positive charge
• Nucleophiles attack because they want to get rid of their electrons
• Electrophiles accept because they want electrongs
• Ketone acts as a nucleophile in acidic conditions because its O carries a negative charge
• Ketone acts as electrophile in basic conditions because its C bears a positive charge
• This is structure of a ketone

  
• In ATP hydrolysis, water is nucleophile and phosphoanhydrate bond is electrophile
• ATP hydrolysis yields ADP, phosphate group with OH and H+
• Nucleophiles are also called Lewis base
• Electrophiles are also called Lewis acid