Respirovirus, Pneumovirus, Rubulavirus, Morbillivirus.

• Genus Respirovirus, Pneumovirus belongs to the family of Paramyxovidae, which are RNA viruses with negative polarity.
• Respirovirus and Pneumovirus have a lipidic membrane with M protein, an envelope with L and P proteins, and a nucleocapsid.
• Respirovirus and Pneumovirus are made by Paramyxovinae, which include Respirovirus (parainfluenza type 1, 3), Rubulavirus (parainfluenza type 2, 4a and b + parotid virus), and Morbillivirus (measles virus).
• Virons bind to sensible cells through HN protein in external cellular membrane.
• Protein F interacts with the plasmatic membrane and fuses the infected cell.
• Respirovirus, Rubulavirus have hemagglutinin (H) and neuraminidases (N) activity, salicylic acid receptor.
• Morbillivirus has H activity, CD46 receptor.
• Pneumovirus does not have H or N activity.
• Parainfluenza virus of type 1 and 3 are limited infections to the epithelium of respiratory ways.
• Respirovirus and Rubulavirus multiply into the penetration point, generally only in the naso-pharynx of adults and extend to the trachea, bronchi, bronchioles, alveolus in children.
• Respirovirus and Rubulavirus cause weak immunity, leading to reinfections.
• Respirovirus and Rubulavirus do not provoke epidemic cases.
• Respirovirus and Rubulavirus have a cytopathic effect that is very slow.
• Respirovirus and Rubulavirus are diagnosed through symptomatology and isolation of virus.
• Metapneumovirus is a syncytial respiratory virus that causes infections in the superior respiratory ways, bronchiolitis, and pulmonitis.
• Metapneumovirus is diagnosed through isolation and genomic sequence.
• Rubulavirus is a parainfluenza virus type 2, 4a and b, which is identical to respirovirus, and causes enlargement of parotid glands, fever, and spontaneous healing.
• Complications of Rubulavirus include pancreas, CNS, orchitis, testicular atrophia.
• Rubulavirus is transmitted interhuman and salivary infection, with an incubation of 15 days, and grows in chicken embryo.
• Morbillivirus, also known as measles virus, causes inhalation infection, with an incubation of 9-12 days, and multiplies where the CD46 receptor is present.
• Morbillivirus is transmitted through blood, lymph to lymph nodes, MALT, and causes fever, general disturbances, macule- papule exanthema.
• Morbillivirus causes spontaneous healing, but complications can include pulmonary lesions, meningitis, encephalitis.
• Pess (panencephalitis sclerosant subacute) is a complication of Morbillivirus, also known as Dawson encephalitis or leukoencephalitis, with a high mortality rate, usually in children or adolescents, and findings of high neutralizing antibodies and eosinophils inclusions.
• Vaccines against Morbillivirus are attenuated live virus.