3.8.3 using genome projects

• What is the genome?

  The complete set of genetic information contained in the cells of an organism
• What is genome sequencing? 


  Identifying the DNA base sequence of an individual. This allows us to determine the amino acid sequence of the polypeptides coded for by that DNA
• Proteome 


  The complete set of all proteins that can be produced by a cell
• Can we directly translate the genome into the proteome?

  In simple organisms, yes. In complex organisms, due to the presence of non-coding DNA and regulatory genes, it is much harder to obtain the proteome
• Applications of sequencing the proteome 


  Identifying potential antigens for use in vaccine production
• Applications of genome sequencing 


  Comparing genomes between species to determine evolutionary relationships

  Genetic matching

  Personalised medicine

  Synthetic biology