Anaerobic Respiration

• an example of TCS is anaerobic respiration (PhoR/PhoP system regulates expression of genes required for phosphate uptake)

  • PhoR HK is off when phosphate bound
  • PhoR HK is on when not phosphate bound/low phosphate -> kinase domain auto phosphorylates -> transfer P to PhoP RR to become TF then turn on res ABCDE operon

  
• PhoR/PhoP system regulates expression of genes required for phosphate uptake
• ResD/ResE system regulates expression of genes required for anaerobic respiration, senses low oxygen
• an example of TCS is anaerobic respiration (ResD/ResE system regulates expression of genes required for anaerobic respiration, senses low oxygen)

  • phosphorylated PhoP RR/TF turns on res ABCDE
  • res ABC are genes responsible for anaerobic respiration (make ATP)
  • res DE form another TCS:
  • resE -> HK sensor
  • resD -> RR, when phosphorylated it becomes TF and turns on phoR and phoP genes ==> positive feedback loop!