Uausus

• What route of administration is available for Diazepam that serves a specific purpose?

  Rectal preparation
• What condition are some antiepileptic drugs best suited to treat?

  Status epilepticus
• What are the two routes of administration for Carbamazepine (Tegretol)?

  Orally and IV
• What is the mechanism of action of Carbamazepine (Tegretol)?

  Inhibits voltage-gated sodium channels
• What type of seizures does Carbamazepine treat?

  Focal and generalized tonic-clonic
• Besides seizures, what else does Carbamazepine treat?

  Trigeminal neuralgia, bipolar disorder
• What are common side effects of Carbamazepine?

  Dizziness, hyponatremia, blood dyscrasias
• What effect does Carbamazepine have on CYP450 enzymes?

  Induces CYP450 enzymes
• Why should Carbamazepine not be prescribed for patients with absence seizures?

  It can exacerbate the condition
• What is the route of administration for Lacosamide (Vimpat)?

  Orally
• What is the mechanism of action of Lacosamide (Vimpat)?

  Inhibits voltage-gated sodium channels
• What kind of seizures is Lacosamide (Vimpat) indicated for?

  Focal seizures; tonic-clonic seizures
• What are common side effects of Lacosamide (Vimpat)?

  Dizziness, headache, nausea, diplopia
• Does Lacosamide (Vimpat) bind to plasma proteins?

  No, it does not
• What effect does Lacosamide have on CYP450 enzymes?

  Does not induce CYP450 enzymes
• What is the route of administration for Lamotrigine (Lamictal)?

  Orally
• What is the mechanism of action of Lamotrigine?

  Inhibits sodium channels, glutamate release
• What conditions does Lamotrigine treat?

  Focal, generalized seizures, bipolar disorder
• What are common side effects of Lamotrigine?

  Hepatotoxicity, thrombocytopenia, weight gain
• What effect does Lamotrigine have on CYP450 enzymes?

  Induces CYP450 enzymes
• What adjustment should be made when adding valproate to a Lamotrigine therapy?

  Reduce lamotrigine dosages
• What should not be done abruptly when taking Lamotrigine?

  Stopped abruptly
• What are the routes of administration for Leviteracetam (Keppra)?

  Orally and IV
• What is the mechanism of action of Levetiracetam (Keppra)?

  Binds to synaptic vesicle protein SV2A
• What types of seizures does Levetiracetam treat?

  Focal and generalized seizures
• What are common side effects of Levetiracetam?

  Irritability, mood swings, dizziness, fatigue
• How is Levetiracetam generally tolerated?

  Generally well-tolerated
• What is the route of administration for Oxcarbazepine (Trileptal)?

  Orally
• What is the mechanism of action of Oxcarbazepine?

  Inhibits voltage-gated sodium channels
• What types of seizures does Oxcarbazepine treat?

  Focal seizures, generalized seizures
• What are common side effects of Oxcarbazepine?

  Dizziness, somnolence, hyponatremia, rash
• How does Oxcarbazepine compare to carbamazepine regarding enzyme induction?

  Less potent enzyme induction
• What adverse effect limits the use of Oxcarbazepine in the elderly?

  Hyponatremia
• What is the route of administration for Phenobarbital?

  Orally
• What is the mechanism of action of Phenobarbital?

  Enhances GABAergic activity
• What conditions does Phenobarbital treat?

  Focal, generalized seizures, status epilepticus
• What are common side effects of Phenobarbital?

  Sedation, CNS depression, bradycardia
• What are some potential issues associated with Phenobarbital?

  Teratogenic, induces CYP450 enzymes
• What are the routes of administration for Phenytoin (Dilantin)?

  Orally and IV
• What is the mechanism of action of Phenytoin?

  Inhibits voltage-gated sodium channels