It ignores the nurture debate as the brain still needs to interact with what is happening in the environment to be able to produce symptoms like hallucinations therefore biological factors aren't enough
It is too reductionist as it focuses on one part of the brain or one neurochemical and there could be other factor. therefore it is too simplistic as biological reasons could be part of the explanation
Brain dysfunction could be and effect of schizophrenia not a cause as we don't know what came first therefore brain structure may change after something has triggered it