W2HEMA2LEC

• Thrombopoietin


  hormone that stimulates the production and maturation of megakaryocytes
• Thrombocytes/Platelets

  cells involved in thrombopoiesis
• Sinusoids

  - capillaries in the liver

  - Found in BM, Spleen and liver
• Capillaries

  - Responsible for microcirculation that links between arterial and venous circulation

  
  

  - Thinnest walled and most numerous of blood vessels composes of basement membrane that is tightly anchored with collagen that offers support for microvascular unit
• Venules

  smallest veins

  
  

  - microscopic size of veins connecting to capillaries
• Arterioles


  microscopic arteries that connect with capillaries

  
  

  - microscopic continuation of arteries giving off metarterioles joining capillaries
• Arterioles and Venules

  smaller blood vessels/ arteries and veins
• Tunica Adventitia/ Tunica Externa


  consist offibrous connective tissue with nerve endings, small networks of blood vessels

  
  

  -supplies nutrients to the tissues of the wall
• Tunica Media


  Thickess coatand ccomposed ofsmooth muscle and elastic fibers
• Tunica Intima


  single layer endothelium cells thickened by sub-endothelial connective tissue layer and contains elastic fibers
• Blood Vasculature

  coated into 3 layers
• Fibrinolysis


  Breakdown and removal of a clot
• Primary Hemostasis

  platelet plug formation
• Vasodilation


  widening of blood vessels to bring back the blood flow normal
• Vasoconstriction

  Reduces blood flow and heat transfer by decreasing the diameter of superficial blood vessels.
• - Complement System

  - Kinin System

  - Serine System


  other components of hemostasis
• 1). Vascular system

  2). Platelets/Thrombocytes

  3). Blood coagulation factors

  4). Fibrinolysis

  components of hemostasis
• Haemorrhagic responses & Thrombosis

  Hemostasis are maintained by
• Hemostasis


  stoppage of bleeding