Tissues fluid formation starts at the arteriole end, there is a higher hydrostatic pressure than osmotic pressure, water containing glucose, amino acids and dissolved ions is forced out of the capilliary, this fluid bathes the tissues and glucose and ion uptake occurs, proteins remain in the capilliary reducing water potential, hydrostatic pressure is reduced toward the venule so osmotic pressure becomes greater by comparison, some water reenters the capilliary, the rest of the water returns to circulation via the lymphatic system