The main effect is to stimulate the release of thyrotropin (also known as thyroid stimulating hormone) from the pituitary gland. Thyrotropin-releasing hormone is the master regulator of thyroid gland growth and function, including the secretion of the thyroid hormones thyroxine and triiodothyronine. These hormones control the body's metabolic rate, heat generation, neuromuscular function and heart rate, among other things.