Circulatory systems can be open (in insects) or closed (in fish and mammals)
Closed circulatory systems come in two forms:
Single form: heart with two chambers, blood passes through the heart once for every circuit of the body
Double form: heart with four chambers, blood passes through the heart twice for every circuit of the body
Important structures and functions in the circulatory system:
Arteries: carry blood away from the heart, thick-walled to withstand high blood pressure, contain elastic tissue to stretch and recoil, contain smooth muscle to vary blood flow, lined with smooth endothelium to reduce friction
Arterioles: branch off arteries, have thinner and less muscular walls, feed blood into capillaries
Capillaries: smallest blood vessels, site of metabolic exchange, one cell thick for fast exchange of substances
Venules: larger than capillaries but smaller than veins
Veins: carry blood from the body to the heart, contain a wide lumen to maximize blood volume, thin-walled under low pressure, contain valves to prevent backflow of blood
Tissue fluid:
Liquid containing dissolvedoxygen and nutrients
Enables exchange of substances between blood and cells
Hydrostatic pressure:
Created when blood is pumped along arteries, arterioles, and capillaries
Forces blood fluid out of the capillaries
Only small enough substances can escape through capillary walls to form tissue fluid
Lymphatic system:
Carries remaining tissue fluid back via lymph fluid
Contains lymph nodes to filter out bacteria and foreign material
Lymph fluid carries waste products
Mammalian heart and cardiac cycle:
Heart is myogenic
Sinoatrial node in the right atrium is the pacemaker
Atrial systole, ventricular systole, cardiac diastole are the 3 stages of the cardiac cycle
Haemoglobin:
Water-solubleglobular protein with two alpha and two betapolypeptide chains
Carries oxygen in the blood, each molecule can carry fouroxygen molecules
Affinity of oxygen for haemoglobin varies with partial pressure of oxygen
Fetal haemoglobin has a higher affinity for oxygen compared to adult haemoglobin
Affinity of haemoglobin for oxygen is affected by the partial pressure of carbon dioxide (Bohr effect)
The heart is made up of four chambers, two atria (upper) and two ventricles (lower).