IS history

• 1901- Emil von Behring- Serum antitoxins
• 1905- Robert Koch -Cellular immunity in TB
• 1908- Elie Metchnikoff, Paul Erlich - Phagocytosis: Immunity
• 1913- Charles Richet- Anaphylaxis
• 1919- Jules Bordet -Complement
• 1930- Karl Landsteiner: - Human  blood group antigens
• 1960 -Macfarlane Burnet, Peter Medawar- Discovery of immunologic tolerance
• 1972- Gerald Edelman, Rodney Porter- Structure of antibodies
• 1977- Rosalyn Yalow- Radioimmunoassay
• 1980- George Snell, Jean Dausset, Baruj Benaceraf- Major histocompatibility complex
• 1984- Niels Jerne George Koehler, Cesar Milstein -Immunoregulation

  Monoclonal antibody
• 1987- Susumu Tonegawa- Antibody diversity
• 1991- Edward Donnall Thomas, Joseph Murray- Transplantation
• 1996- Peter Doherty, Rolf Zinkemagel- Cytotoxic T cell recognition of virally infected cells
• 2008- Francoise Barre-Sinoussi, Luc Montagnier- Human immunodeficiency virus
• 1798- Jenner- Smallpox vaccination
• 1862- Haeckel- Phagocytosis
• 1880-1881- Pasteur- Live, attenuated chicken, cholera and anthrax vaccines
• 1883-1905- Metchnikoff -Cellular theory of immunity through phagocytosis
• 1885- Pasteur- Therapeutic vaccination First report of live “attenuated” vaccine for rabies
• 1890- Von Behring- Humoral theory of immunity proposed
• 1891- Koch- Demonstration of cutaneous delayed-type I hypersensitivity
• 1900- Ehrlich- Antibody formation theory
• 1902- Portier, Richet- Immediate-hypersensitivity anaphylaxis
• 1903- Arthus- Arthus reaction of intermediate hypersensitivity
• 1938- Merrack- Hypothesis of antigen-antibody binding
• 1949- Salk, Sabin- Development of polio vaccine
• 1951- Reed- Vaccine against yellow fever
• 1957- Burnet- Clonal selection theory
• 1975- Kohler- First monoclonal antibodies
• 2005- Frazer- Development of human papillomavirus vaccine
• 1798- Edward Jenner,- an English countryside physician demonstrated that protection from cowpox could be generated by the transfer of postural material from a cowpox lesion instead of the more hazardous smallpox lesion.
• 1880- Louis Pasteur- demonstrated that injection of killed microbes provided protection upon subsequent exposure to live counterpart.
• 1888- Elie Metchnikoff- demonstrated that certain blood cells ingest foreign materials
• 1894- Jules Bordet- discovered complement
• 1897- Robert Kaus- discovered precipitins
• 1901- Emil von Behring- had the distinction of being awarded as the first immunology-related Nobel Prize for his works on serum therapy
• 1984 -Discovery of the T cell receptor gene
• 1987- Susumu Tonegawa - was awarded the Noble Prize for his 1987 discovery of the genetic principles underlying the generation of antibodies with different specificities