Seasonal affective disorder is an example of the influence of endogenous pacemakers on the circadian sleep-wake cycle. SAD is an infradian disorder caused by disruption to the sleep-wake cycle, and commonly occurs in the winter. Longer nights means that more melatonin is secreted from the pituitary gland, via the endocrine system, which changes the production of melatonin, leading to feelings of loneliness and depression