With osteoporosis, estrogen maintains bone density in both genders. It inhibits resorption (breakdown) by osteoclasts though. In fact, postmenopausal white women are at the greatest risk because their ovaries cease to secrete estrogen. White women begin to lose bone mass as early as age 35, and by age 70, the average loss is 30% of bone mass. Risk factors for osteoporosis include: race, age, gender, smoking, diabetes mellitus, and diets that are poor in: calcium, protein, vitamins C and vitamin D.