Although antidepressant drugs are successful for many patients, they don't work for everyone. In a recent study by Cipriani et al, they compared 21 antidepressant drugs and found wide variations in effectiveness. Although most drugs were more effective than placebos in comparative trials. Researchers then concluded that the effects of antidepressants was 'mainly modest'. This challenges the value of this approach, as it suggests that brain chemistry alone may not account for all cases, e.g. depression.