Microbiological Sources

• Penicillium notatum is a fungus which gives penicillin
• Actinobacteria give Streptomycin
• Aminoglycosides such as gentamicin and tobramycin are obtained from streptomycis and micormonosporas
• involves cleavage of DNA by enzyme restriction endobucleases

  Recombinant DNA Technology
• The desired gene is coupled to rapidly replicating DNA (viral, bacteria or plasmid)

  Recombinant DNA Technology
• The new genetic combination is inserted into the bacterial cultures which allow production of vast amount of genetic material

  Recombinant DNA Technology
• Advantages of Recombinant DNA Technology:

  • Huge amounts of drugs can be produced
  • Drug can be obtained in pure form
  • It is less antigenic
• Disadvantages of Recombinant DNA Technology:

  • Well equipped lab is required
  • Highly trained staff is required
  • it is a complex and complicated technique