Toxicity: in high concentrations eg CO2 dissolves in water -> acidic solution = lower the pH of cells -> reduce enzyme activity for metabolic reactions
Osmotic effect: body fluids can become more concentrated (hypertonic) due to higher amounts of waste products which can cause water to move out of cells, changing their water potential (crenation) and preventing them from carrying out essential reactions
storage: space within an organism is limited and is required for the storage of more useful molecules