Rheumatoid arthritis (RA) is an autoimmune attack against the joint tissues. In this arthritis, misguided antibodies (rheumatoid factor) attackthe synovial membrane, enzymes in synovial fluid degrade the articular cartilage, and then the joint begins to ossify. Ankylosis makes a solidly fused, immobilized joint. Although remissions occur, steroids and aspirin control inflammation. Arthroplasty is the replacement of the diseased joint with an artificial device called a prosthesis.