CONNECTIVE TISSUES

Cards (32)

  • Connective tissue
    → It provides support, binds together, and protects tissues and organs of the body.

    CONSISTS PRIMARILY OF EXTRACELLULAR MATERIAL
  • 1. Cells

    2. Fibers

    3. Amorphous Ground substance
    Three Main Components of Connective Tissue
  • Fixed Cells
    For connection and protection
  • I. FIXED CELLS

    MESENCHYMAL CELLS (FIXED CELLS)

    A multipotent stromal cells that can differentiate into a variety of cell types
  • MOTHER CELLS
    that can differentiate on a different types of cell
  • 2 CATEGORIES OF MESENCHYMAL CELLS
    1. FIBROBLASTS

    2. RETICULAR CELLS
  • Fibroblasts
    Most common cell

    Produce and maintain the extracellular matrix
  • Fibroblasts synthesizes?
    Synthesize(produce) collagen, elastin, glycosaminoglycan, proteoglycan, and multi adhesive glycoprotein
  • Reticular Cells
    A type of fibroblast that synthesizes type III collagen and uses it to produce reticular fibers

    Traps potentially harmful substances; supports antigen presenting cells
  • Blast
    baby / immature cells
  • Cyte
    mature / adult
  • I. FIXED CELLS

    MYOFIBROBLASTS
    Both a fibroblast and smooth muscle

    Wound closure
  • I. FIXED CELLS

    ADIPOCYTES
    Are very large cells specialized for storage of TAG,
    neutral fats

    Production of heat

    adipose tissue
  • two types of adipose tissue:
    o White fat - long-term storage of energy

    o Brown fat - generation of heat (thermogenesis)
  • II. WANDERING CELLS
    Mostly for the immune part of connective tissue
  • II. WANDERING CELLS:

    MACROPAHGES
    Cells that have phagocytic ability (cell eating)

    Came from monocytes
  • II. WANDERING CELLS:

    MAST CELLS
    • Cytoplasm is filled with basophilic secretory granules

    • Associated with anaphylaxis (allergic reaction)

    • Abundant in the dermis, digestive and respiratory
  • II. WANDERING CELLS:

    PLASMA CELLS

    • A type of immune cell that makes large amounts of a specific antibody
  • PLASMA CELLS develop from
    B lymphocytes (Bcells)
  • FIBERS (CONNECTIVE TISSUE)
    I. COLLAGEN FIBERS

    II. RETICULAR FIBER

    III. ELASTIC FIBER
  • I. COLLAGEN FIBERS
    Most abundant protein (fiber) in the body

    → Give tensile strength to connective tissues
  • Tensile
    ability to withstand tension
  • I. COLLAGEN FIBERS

    COLLAGEN THAT FORMS FIBRILS (I, II, III, V, XI)
    Aggregate to form fibrils
  • Collagens that forms fibrils:
    tendons, organ coverings, yung mga presence and dermis
  • Collagen type I
    is the most abundant and has a widespread distribution
  • I. COLLAGEN FIBERS

    FIBRIL-ASSOCIATED COLLAGEN

    Short structures that bind the surfaces of collagen fibrils to one another and to other components of the ECM
  • FIBRIL-ASSOCIATED COLLAGEN
    It is a subset of collagen that contribute to the organization and stabilization of ECM
  • I. COLLAGEN FIBERS

    COLLAGEN THAT FORMS ANCHORING FIBRILS
    Type VII Collagen

    Bind the basal lamina to reticular fibers in the underlying connective tissue
  • I. COLLAGEN FIBERS

    COLLAGEN THAT FORM NETWORKS
    Type IV Collagen
  • II. RETICULAR FIBER
    Support - network of thin fiber

    → Type III collagen
  • II. RETICULAR FIBER
    Abundant in hematopoietic organs (may kinalaman sa pagproduce ng blood)
  • III. ELASTIC FIBER
    → Contain elastin and fibrillin

    → Gives connective tissues stretch and resiliency