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CONNECTIVE TISSUES
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Connective tissue
→ It provides
support
, binds
together
, and
protects tissues
and
organs
of the
body.
→
CONSISTS PRIMARILY OF EXTRACELLULAR MATERIAL
1.
Cells
2.
Fibers
3.
Amorphous Ground substance
Three Main Components
of
Connective Tissue
Fixed Cells
For connection and protection
I.
FIXED CELLS
MESENCHYMAL CELLS
(FIXED CELLS)
A
multipotent stromal cells
that can
differentiate
into a
variety
of
cell types
MOTHER CELLS
that can differentiate on a different types of cell
2 CATEGORIES OF MESENCHYMAL CELLS
1.
FIBROBLASTS
2.
RETICULAR CELLS
Fibroblasts
Most
common cell
Produce and maintain the
extracellular matrix
Fibroblasts synthesizes?
Synthesize
(produce)
collagen
,
elastin
,
glycosaminoglycan
,
proteoglycan
, and
multi adhesive glycoprotein
Reticular Cells
A type of
fibroblast
that synthesizes
type III collagen
and uses it to produce
reticular fibers
Traps potentially
harmful substances
; supports
antigen presenting cells
Blast
baby
/
immature
cells
Cyte
mature
/
adult
I. FIXED CELLS
MYOFIBROBLASTS
Both a
fibroblast
and
smooth muscle
Wound closure
I. FIXED CELLS
ADIPOCYTES
Are very
large cells specialized
for
storage
of
TAG
,
neutral fats
Production
of
heat
adipose tissue
two types of adipose tissue:
o
White fat
-
long-term
storage of
energy
o Brown
fat
- generation of
heat
(
thermogenesis
)
II.
WANDERING CELLS
Mostly for the immune part of connective tissue
II.
WANDERING CELLS
:
MACROPAHGES
Cells that have
phagocytic
ability (cell eating)
Came from
monocytes
II. WANDERING CELLS:
MAST CELLS
• Cytoplasm is filled with
basophilic secretory granules
• Associated with
anaphylaxis
(
allergic reaction
)
• Abundant in the
dermis
,
digestive
and
respiratory
II. WANDERING
CELLS
:
PLASMA
CELLS
• A type of immune cell that makes large amounts of a specific antibody
PLASMA CELLS develop from
B lymphocytes
(
Bcells
)
FIBERS (CONNECTIVE TISSUE)
I. COLLAGEN FIBERS
II. RETICULAR FIBER
III. ELASTIC FIBER
I.
COLLAGEN FIBERS
→
Most abundant protein
(fiber) in the body
→ Give
tensile strength
to
connective tissues
Tensile
ability to withstand tension
I. COLLAGEN FIBERS
COLLAGEN THAT FORMS FIBRILS (I, II, III, V, XI)
Aggregate
to
form fibrils
Collagens that forms fibrils:
tendons
,
organ coverings
,
yung mga presence
and
dermis
Collagen type I
is the most abundant and has a widespread distribution
I. COLLAGEN FIBERS
FIBRIL-ASSOCIATED
COLLAGEN
Short structures that bind the surfaces of collagen fibrils to one another and to other components of the ECM
FIBRIL-ASSOCIATED COLLAGEN
It is a subset of collagen that contribute to the organization and stabilization of ECM
I. COLLAGEN FIBERS
COLLAGEN THAT FORMS ANCHORING FIBRILS
Type VII Collagen
Bind the
basal lamina
to
reticular fibers
in the underlying
connective tissue
I. COLLAGEN FIBERS
COLLAGEN THAT FORM NETWORKS
Type IV Collagen
II. RETICULAR FIBER
Support
- network of thin fiber
→ Type
III
collagen
II. RETICULAR FIBER
Abundant in
hematopoietic organs
(may
kinalaman
sa
pagproduce
ng
blood
)
III.
ELASTIC
FIBER
→ Contain
elastin
and
fibrillin
→ Gives
connective tissues stretch
and
resiliency