assignments 4-6

Cards (39)

  • Widening of blood vessels called ___________________ increases blood flow to an infected area and results in the heat and redness often associated with inflammation.
    vasodilation
  • During an inflammatory response, leaky blood vessels allow fluid to leak from the blood into tissues, causing a swelling that is referred to as ___________________
    oedema
  • An infection in the blood can result in blood vessels becoming leaky throughout the body, leading to a massive loss of blood pressure and insufficient delivery of oxygen to the body that is referred to as __________________

    shock
  • Blood clotting is an essential part of wound healing to stop bleeding, but an inappropriate clotting response called _________________ can occur during inflammatory disease.
    thrombosis
  • An inflammatory disease of the liver. ____
    hepatitis
  • A genetic disease that causes persistent activation of the inflammasome, leading to the symptoms of severe infection even when there is no infection. ___________________
    familial Mediterranean fever
  • The presence of pathogens in the bloodstream results in an inflammatory response that is systemic (occurs throughout the body) instead of being localized. __________________
    sepsis
  • An inflammatory disease of the skin. ___
    dermatitis
  • Recruitment of monocytes into arterial walls leads to the formation of lesions called plaques that obstruct blood flow. ___________________
    atherosclerosis
  • A cytokine that is part of the innate immune response to virus infections: _
    _______________interferon a
  • A cytokine that is a general growth factor for many blood cells including stem cells: ___________________
    IL-3
  • An immunosuppressive cytokine: _____
    IL-10
  • A protein that belongs to the chemokine family of cytokines and functions as a chemoattractant for neutrophils: _____
    IL-8
  • A lipid chemoattractant for neutrophils: ___
    leukotriene B4
  • A cytokine that promotes differentiation of helper T cells to the TH1 subset: __
    interferon gamma
  • A cytokine that promotes differentiation of helper T cells to the TH2 subset: ____
    IL-4
  • A primary cytokine that has both local and systemic actions that orchestrate and amplify an inflammatory response: _______________
    tumor necrosis factor
  • A cytokine that stimulates T cell division, for example it is needed for clonal amplification of T cells: ___________
    IL-2
  • An adhesion molecule that is induced in neutrophils to establish strong binding to the blood vessel wall during the process of chemoattraction:______
    integrin
  • Helper T cell subset associated with parasitic infections and allergy _____________
    TH2
  • Antibody associated with parasitic infections and allergy ______________
    IgE
  • Antibody transported across epithelia and present in secretory fluids ______________
    IgA
  • Antibody that facilitates phagocytosis of pathogens by neutrophils and macrophages; it is the predominant type of antibody in blood ______________
    IgG
  • Helper T cell subset that stimulates B cell antibody class switching to IgG and super-activates macrophages by direct contact ______________
    TH1
  • A TH1 response to a bacterial infection ____
    tuberculosis
  • A TH2 response to a parasitic helminth infection _____
    schistosomiasis
  • An inappropriate TH1 response and cytotoxic T cell response is triggered by dietary gluten (a harmless food protein) in the gut, and the tissue damage results in destruction of the upper small intestine ____________________
    Celiac disease
  • An inappropriate TH2 response to a bacterial infection is produced instead of the required TH1 response, and it results in a clinically severe form of the disease.
    _______
    lepromatous leprosy
  • An inappropriate TH2 response to harmless molecules such as pollen _____________________
    allergy
  • A component of the membrane attack complex: __
    C9
  • The major opsonin: __________________
    C3b
  • An inflammatory mediator, referred to as an anaphylatoxin: __________________
    C5a
  • Binds to antibody and initiates the complement cascade: __
    C1
  • A component of the C3 convertase: __________________
    C2a
  • Regulatory T cells (Treg)_____
    Help to establish tolerance to harmless molecules such as food proteins.
  • M cells____
    Sample gut antigens and deliver them to dendritic cells, which enables production of effector B and T cells that stand guard.
  • Goblet cells____

    Secretion of mucous
  • TH17 cells
    Participate in the normal homeostasis of the gut, they induce production of antimicrobial peptides
  • Paneth cells
    Secretion of defensins