Widening of blood vessels called ___________________ increases blood flow to an infected area and results in the heat and redness often associated with inflammation.
vasodilation
During an inflammatory response, leaky blood vessels allow fluid to leak from the blood into tissues, causing a swelling that is referred to as ___________________
oedema
An infection in the blood can result in blood vessels becoming leaky throughout the body, leading to a massive loss of blood pressure and insufficient delivery of oxygen to the body that is referred to as __________________
shock
Blood clotting is an essential part of wound healing to stop bleeding, but an inappropriate clotting response called _________________ can occur during inflammatory disease.
thrombosis
An inflammatory disease of the liver. ____
hepatitis
A genetic disease that causes persistent activation of the inflammasome, leading to the symptoms of severe infection even when there is no infection. ___________________
familial Mediterranean fever
The presence of pathogens in the bloodstream results in an inflammatory response that is systemic (occurs throughout the body) instead of being localized. __________________
sepsis
An inflammatory disease of the skin. ___
dermatitis
Recruitment of monocytes into arterial walls leads to the formation of lesions called plaques that obstruct blood flow. ___________________
atherosclerosis
A cytokine that is part of the innate immune response to virus infections: _
_______________interferon a
A cytokine that is a general growth factor for many blood cells including stem cells: ___________________
IL-3
An immunosuppressive cytokine: _____
IL-10
A protein that belongs to the chemokine family of cytokines and functions as a chemoattractant for neutrophils: _____
IL-8
A lipid chemoattractant for neutrophils: ___
leukotriene B4
A cytokine that promotes differentiation of helper T cells to the TH1 subset: __
interferon gamma
A cytokine that promotes differentiation of helper T cells to the TH2 subset: ____
IL-4
A primary cytokine that has both local and systemic actions that orchestrate and amplify an inflammatory response: _______________
tumor necrosis factor
A cytokine that stimulates T cell division, for example it is needed for clonal amplification of T cells: ___________
IL-2
An adhesion molecule that is induced in neutrophils to establish strong binding to the blood vessel wall during the process of chemoattraction:______
integrin
Helper T cell subset associated with parasitic infections and allergy _____________
TH2
Antibody associated with parasitic infections and allergy ______________
IgE
Antibody transported across epithelia and present in secretory fluids ______________
IgA
Antibody that facilitates phagocytosis of pathogens by neutrophils and macrophages; it is the predominant type of antibody in blood ______________
IgG
Helper T cell subset that stimulates B cell antibody class switching to IgG and super-activates macrophages by direct contact ______________
TH1
A TH1 response to a bacterial infection ____
tuberculosis
A TH2 response to a parasitic helminth infection _____
schistosomiasis
An inappropriate TH1 response and cytotoxic T cell response is triggered by dietary gluten (a harmless food protein) in the gut, and the tissue damage results in destruction of the upper small intestine ____________________
Celiac disease
An inappropriate TH2 response to a bacterial infection is produced instead of the required TH1 response, and it results in a clinically severe form of the disease.
_______
lepromatous leprosy
An inappropriate TH2 response to harmless molecules such as pollen _____________________
allergy
A component of the membrane attack complex: __
C9
The major opsonin: __________________
C3b
An inflammatory mediator, referred to as an anaphylatoxin: __________________
C5a
Binds to antibody and initiates the complement cascade: __
C1
A component of the C3 convertase: __________________
C2a
Regulatory T cells (Treg)_____
Help to establish tolerance to harmless molecules such as food proteins.
M cells____
Sample gut antigens and deliver them to dendritic cells, which enables production of effector B and T cells that stand guard.
Goblet cells____
Secretion of mucous
TH17 cells
Participate in the normal homeostasis of the gut, they induce production of antimicrobial peptides