Glucose is phosphorylated to glucose phosphate using 2ATP
Each glucose phosphate is converted to 2 Triose phosphate
Triose phosphate is oxidised to pyruvate producing 2ATP and 1 NADH (reduced NAD)
Link reaction
pyruvate is decarboxylated to acetate
NAD is converted to NADH and 1 mol of CO2 is produced
acetate combines with Coenzyme A to produce Acetylcoenzyme A
Krebs cycle:
Acetylcoenzyme A combines with a 4C acceptor molecule releasing Coenzyme A and producing a 6C intermediate (citrate)
6C intermediate is decarboxylated releasing CO2 and oxidised producing NADH and a 5C intermediate
5C intermediate is oxidised further to reproduce the 4C acceptor molecule, releasing 1 ATP, 2 NADH, 1 FADH
Oxidative phosphorylation:
the NADH produced in glycolysis and Krebs cycle donate electrons to the first molecule in the electron transport chain.FADH donates electrons to the second molecule in the electron transport chain.
as electrons pass along the ETC they release energy, used to activelytransport H+ across the cristae membrane.
This results in an electrochemical gradient and the H+ now diffuse back into the matrix through ATP synthase channels. synthesising ATP by phosphorylation of ADP
oxygen is the final electron acceptor in the electron transport chain!!
when is ATP made in glycolysis
when TP converted to pyruvate
when is ATP used in glycolysis
converting glucose to glucose phosphate
Oxygen is the terminal/ final electron acceptor in the electrontransfer chain.
Under anaerobic conditionslink reaction and krebs cycle cannot take place, only glycolysis can take place without oxygen.
In mammels pyruvate is converted to lactate (lactic acid) which also converts NADH back to NAD for reuse in glycolysis producing 2 ATP
In yeast pyruvate in converted to ethanol which also converts NADH to NAD for reuse in glycolysis producing 2 ATP