reoviridae

Cards (31)

  • What does the name Reovirus originate from?
    Respiratory and enteric viruses
  • What type of viruses are Reoviridae?
    Non-enveloped viruses
  • What is the diameter range of Reoviridae?
    60-80 nm
  • What is the structure of the Reoviridae genome?
    10-12 segments of double-stranded RNA
  • What is the total genome size of Reoviridae?
    Approximately 27kb
  • What does reassortment of gene segments refer to?
    Mixing of gene segments among viruses
  • What is the diameter of Rotaviruses?
    70 nm
  • How many protein layers does the Rotavirus capsid have?
    Three circular protein layers
  • What is the significance of the VP6 protein in Rotaviruses?
    It groups Rotaviruses (A-G)
  • What does the name Rotavirus refer to?
    Its wheel-like appearance
  • What are the important genera of Reoviridae for human pathology?
    • Orthoreovirus: Milder URT and GIT illness
    • Orbivirus/Coltivirus: Febrile illness with headache
    • Rotavirus: Major cause of gastroenteritis
  • How does Rotavirus survive in the stomach?
    It withstands the acidic environment
  • What is the effect of Rotavirus infection on water absorption?
    Prevents water absorption, causing diarrhea
  • What role does the NSP4 protein play in Rotavirus infection?
    Acts in a toxin-like manner
  • What can fluid and electrolyte loss from Rotavirus lead to?
    Severe dehydration
  • In which age group is Rotavirus disease most significant?
    Infants younger than 24 months
  • How is Rotavirus primarily spread?
    Fecal-oral and air route
  • What percentage of children are infected with Rotavirus by age 5?
    95%
  • What environmental conditions can the Rotavirus capsid resist?
    Environmental and gastrointestinal conditions
  • When is Rotavirus disease most common?
    Autumn, winter, and spring
  • What is the incubation period for Rotavirus?
    48 hours
  • What are common symptoms of Rotavirus infection?
    Vomiting, diarrhea, fever, dehydration
  • What is the primary method for laboratory diagnosis of Rotavirus?
    Faecal samples
  • What types of cell cultures are used for Rotavirus diagnosis?
    Intestinal epithelium and MA-104
  • What does agglutination testing for Rotavirus indicate?
    Presence of antibodies in the serum
  • Is there a specific antiviral therapy for Rotavirus?
    No specific antiviral therapy is available
  • What is the focus of treatment for Rotavirus infection?
    Managing dehydration, vomiting, and diarrhea
  • What type of vaccine is recommended for Rotavirus prevention?
    Oral live vaccine
  • At what age should infants receive the Rotavirus vaccine?
    6 weeks to 24 weeks
  • How many doses of the Rotavirus vaccine are recommended?
    Two doses
  • How far apart should the doses of the Rotavirus vaccine be given?
    4 weeks apart