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Microbiology
Virology
reoviridae
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Created by
keerthana
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Cards (31)
What does the name Reovirus originate from?
Respiratory
and
enteric
viruses
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What type of viruses are Reoviridae?
Non-enveloped
viruses
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What is the diameter range of Reoviridae?
60-80
nm
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What is the structure of the Reoviridae genome?
10-12
segments
of
double-stranded RNA
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What is the total genome size of Reoviridae?
Approximately
27kb
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What does reassortment of gene segments refer to?
Mixing of gene segments among
viruses
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What is the diameter of Rotaviruses?
70
nm
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How many protein layers does the Rotavirus capsid have?
Three
circular protein layers
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What is the significance of the VP6 protein in Rotaviruses?
It groups Rotaviruses
(
A-G
)
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What does the name Rotavirus refer to?
Its
wheel-like
appearance
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What are the important genera of Reoviridae for human pathology?
Orthoreovirus
: Milder URT and GIT illness
Orbivirus
/
Coltivirus
: Febrile illness with headache
Rotavirus
: Major cause of gastroenteritis
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How does Rotavirus survive in the stomach?
It withstands the
acidic
environment
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What is the effect of Rotavirus infection on water absorption?
Prevents water absorption, causing
diarrhea
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What role does the NSP4 protein play in Rotavirus infection?
Acts in a
toxin-like
manner
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What can fluid and electrolyte loss from Rotavirus lead to?
Severe
dehydration
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In which age group is Rotavirus disease most significant?
Infants younger than
24 months
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How is Rotavirus primarily spread?
Fecal-oral
and air route
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What percentage of children are infected with Rotavirus by age 5?
95%
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What environmental conditions can the Rotavirus capsid resist?
Environmental
and
gastrointestinal
conditions
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When is Rotavirus disease most common?
Autumn
,
winter
, and
spring
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What is the incubation period for Rotavirus?
48
hours
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What are common symptoms of Rotavirus infection?
Vomiting, diarrhea, fever,
dehydration
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What is the primary method for laboratory diagnosis of Rotavirus?
Faecal
samples
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What types of cell cultures are used for Rotavirus diagnosis?
Intestinal epithelium and
MA-104
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What does agglutination testing for Rotavirus indicate?
Presence of
antibodies
in the serum
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Is there a specific antiviral therapy for Rotavirus?
No
specific
antiviral
therapy
is available
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What is the focus of treatment for Rotavirus infection?
Managing
dehydration
, vomiting, and
diarrhea
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What type of vaccine is recommended for Rotavirus prevention?
Oral live vaccine
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At what age should infants receive the Rotavirus vaccine?
6 weeks
to
24 weeks
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How many doses of the Rotavirus vaccine are recommended?
Two
doses
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How far apart should the doses of the Rotavirus vaccine be given?
4
weeks apart
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