AO3

• AO3 - genetic basis

  Gottesman conducted large family studies and found

  • 48% concordance rate between MZ twins
  • 13% between children with 1 schizophrenia parent
  • 9% for siblings with a brother or sister of schizophrenia
  • 17% DZ twins
• CB to genetic factors

  The idea of genetic vulnerability is not 100% concordance rate.

  • There are number of factors within the environment.
• AO3 - dopamine hypothesis

  Leucht used a Meta-analysis of 212 studies. He found that all drug treatment programmes were dopamine was redcued was most effective than the placebo in treating both positive and negative symptoms