Psychosurgery is a biological treatment based on the principle that mental disorders have a physical cause in the brain. One key component is the prefrontal lobotomy, developed by Egas Moniz in the 1930s. This invasive procedure involved severing nerve pathways in the frontal lobe, which is responsible for regulating mood and impulse control. Moniz initially used a leucotome to destroy white matter, aiming to alleviate severe symptoms of depression, OCD and, less successfully, schizophrenia by interrupting thought processes causing distress.