Differences: The chemical messenger is different, in the endocrine system are the hormones, while in the nervous are the neurotransmitters, the speed in the nervous system is so much faster than in the endocrine system, the space the nervous system travels are so short, almost non-existent, while the endocrine system are long. Similarities: The target cells are in both chemicals, the effector are glands and both control and coordinate all the functions of the body.