The chemical reactions that take place in the cytoplasm of the cells are known as the metabolism of the cell.
The rate of the chemical reactions is proportional to the volume of the cell.
The rate at which substances cross the membrane depends on its surface area.
surface area-to-volume ration = surface area / volume
If the surface area-to-volume ratio is too small, the substances will not enter the cell as quickly as they are required.
Surface area-to-volume ratio is also important in relation to heat production and loss: if the ratio is too small, cells may overheat because the metabolism produces heat faster than it is lost over the cells surface.