• Pressure filtration causes the plasma to pass through capillary walls into the tissue fluid surrounding the cells.
• Tissue fluid supplies cells with glucose , oxygen and other substances.
• Carbon dioxide and other metabolic wastes diffuse out of the cells and into the tissue fluid to be excreted.
• Much of the tissue fluid returns to the blood by osmosis.
• Lymphatic vessels absorb excess tissue fluid and return it as lymph to the circulatory system.