MC3 GNB

• Vibrio cholerae

  GS: Gram -

  MR: Comma-shaped bacilli

  MT: +

  AR: aerobic

  Virulence factors

  * shooting star motility

  Toxin: choleragen
• Cholera

  Acute bacterial disease of the GIT characterized by severe diarrhea with rice water stools, massive loss of fluid and electrolytes with characteristics "washer woman's hands" leading to severe dehydration
• Vibrio cholerae

  GS: Gram -

  MR: Comma-shaped bacilli

  MT: +AR: aerobic

  Virulence factors

  * shooting star motility

  Toxin: choleragen
• Salmonella typhi

  GS: Gram -

  MR: bacilli

  MT: +

  AR: F. A

  Virulence factors

  * peritrichous flagella

  *capsule

  *pili
• Salmonella typhi

  GS: Gram -

  MR: bacilli

  MT: +

  AR: F. A

  Virulence factors

  * peritrichous flagella

  *capsule

  *pili
• What is the disease caused by Salmonella typhi?

  Typhoid fever
• Patient comes in presenting fever, diarrhea, rose spots, coma vigil and muttering delirium. What disease is this? and its causative agent

  Typhoid fever caused by Salmonella typhi
• Shigella species

  GS: Gram -

  MR: bacilli

  MT: -

  AR: F. A

  Virulence factors

  * Shiga toxin
• Shigella species

  GS: Gram -

  MR: bacilli

  MT: -

  AR: F. A

  Virulence factors

  * Shiga toxin
• Pt comes in with c/o of initially watery then bloody diarrhea. Name the disease and its causative agent.

  Bacillary Dysentery caused by Shigella species
• Escherichia coli

  GS: Gram -

  MR: bacilli

  MT: +

  AR: F. A

  Virulence factors

  *Endotoxin and enterotoxin
• Escherichia coli

  GS: Gram -

  MR: bacilli

  MT: +

  AR: F. A

  Virulence factors*Endotoxin and enterotoxin
• Name 3 diseases caused by Escherichia coli

  1. Urinary tract infection
  2. Healthcare associated infections
  3. Diarrhea
• Pseudomonas aeruginosa

  GS: Gram -

  MR: bacilli

  MT: +

  AR: O. A

  Virulence factors

  toxin: elastase
• Pseudomonas aeruginosa

  GS: Gram -

  MR: bacilli

  MT: +

  AR: O. A

  Virulence factors

  toxin: elastase
• Pseudomonas aeruginosa

  Diseases: BORHV

  1. Burn wound infection
  2. Otitis media
  3. Respiratory infections
  4. Hot tub folliculitis
  5. Ventilator associated Pneumonia
• Haemophilus influenzae

  GS: Gram -

  MR: bacilli

  MT: -

  AR: F. A

  Virulence factors

  *endotoxin
• Haemophilus influenzae

  GS: Gram -

  MR: bacilli

  MT: -

  AR: F. A

  Virulence factors

  *endotoxin
• Haemophilus influenzae

  Diseases:

  1. Bacterial meningitis
  2. Ear infections
  3. Respiratory infections -acute epiglottitis
  4. pneumonia
• Bordetella pertussis

  GS: Gram -

  MR: bacilli

  MT: -

  AR: F. A

  Virulence factors

  toxin: tracheal cytotoxin
• Bordetella pertussis

  GS: Gram -

  MR: bacilli

  MT: -

  AR: F. A

  Virulence factors

  toxin: tracheal cytotoxin
• Pt comes in with c/o whooping cough, paroxysmal pattern of hacking cough. What is the name of the disease? and its causative agent

  Pertussis caused by Bordetella pertussis
• Yersinia pestis

  GS: Gram -

  MR: bacilli

  MT: -

  AR: F. A

  Virulence factors

  toxin: Yersinia murine toxin (Ymt)
• Yersinia pestis

  GS: Gram -

  MR: bacilli

  MT: -

  AR: F. A

  Virulence factors

  toxin: Yersinia murine toxin (Ymt)
• Pt comes in with black rotting/rotted fingers. With black lesions all over his body. It was said that he was bitten by fleas in the market. Name the disease and the causative agent.

  Bubonic plague caused by Yersinia pestis
• Gardnerella vaginalis

  GS: Gram -

  MR: coccobacilli

  MT: -

  AR: F. A

  Virulence factors

  toxin: Vaginolysin
• Gardnerella vaginalis

  GS: Gram -

  MR: coccobacilli

  MT: -

  AR: F. A

  Virulence factors

  toxin: Vaginolysin
• Pt comes in with c/o of thin, off-white vaginal discharge with fishy odor but no itchiness. Vaginal pH is >4.5, Name the disease and the causative agent

  Bacterial vaginosis caused by Gardnerella vaginalis
• Chlamydia trachomatis

  GS: Gram -

  MR: bacilli

  MT: -

  AR: F. A

  Virulence factors

  toxin: endotoxin and CT135 protein
• Chlamydia trachomatis

  GS: Gram -

  MR: bacilli

  MT: -

  AR: F. A

  Virulence factors

  toxin: endotoxin and CT135 protein
• Chlamydia trachomatis

  Diseases:

  1. Chlamydia
  2. Ophthalmia neonatorum/ inclusion conjunctivitis
• Helicobacter pylori

  GS: Gram -

  MR: bacilli

  MT: +

  AR: Microaerophile

  Virulence factors

  Endotoxin, flagella

  Enzymes:

  Protease

  Urease
• Helicobacter pylori

  GS: Gram -

  MR: bacilli

  MT: +

  AR: Microaerophile

  Virulence factors

  Endotoxin, flagella

  Enzymes:

  Protease

  Urease
• Helicobacter pylori

  Diseases:

  Gastroduodenal ulcer

  Peptic ulcer disease (PUD)
• Helicobacter pylori

  Diseases:

  Gastroduodenal ulcer

  Peptic ulcer disease (PUD)